A protease inhibition strategy based on acceleration of autolysis.
نویسندگان
چکیده
We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.
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عنوان ژورنال:
- Chemical communications
دوره 51 27 شماره
صفحات -
تاریخ انتشار 2015